Our group aims to understand how mitochondria influence brain cells fate and how we can preclude neuroderegulation or neurodegeneration through histone modifications. Specifically, we are focused on Schizophrenia (SZ) and Amyotrophic Lateral Sclerosis (ALS).
In a straight perspective, our project scope is: epigenetic --- mitochondria --- energy ---- neural (neurons and astrocytes) survival.
Moreover, our medium-term strategy is to achieve two distinct perspective:
1) extrapolate our in vitro studies to in vivo experiments using pre- and post-symptomatic adult rodents;
2) establish collaborations to perform studies with patients samples.
Concerning to the last, one of the largest advantage of our project’s data is that their are translational results, thus providing the basis to investigate relevant disease therapeutic modifiers in different disorders not only ALS and SZ, but also Huntington’s disease, Parkinson’s disease and Alzheimer’s disease. Consequently, the investigation proposed herein is a very promising field for neuroprotection.
It is important to highlight that our research interest is not only on neurons, but also on astrocytes since this cell type represents one third of the whole brain cells in addition to maintain a close relation with the blood-brain barrier and be important for neurotransmission, neuronal plasticity and neurotrophic factors release.